Platinum(II) clovers targeting G-quadruplexes and their anticancer activities.
نویسندگان
چکیده
Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.
منابع مشابه
Platinum squares with high selectivity and affinity for human telomeric G-quadruplexes.
Two new Pt(II) squares with quinoxaline-bridges selectively stabilize human telomeric G-quadruplexes with high binding constants (10(7)-10(9) M(-1)) and an unprecedented binding stoichiometric ratio of Pt(II) square/G-quadruplex (6 : 1). This selectivity is likely due to the Pt(II) squares' cube-like shape. Both Pt(II) squares also show significant telomerase inhibition and anticancer efficacy.
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ورودعنوان ژورنال:
- Dalton transactions
دوره 44 1 شماره
صفحات -
تاریخ انتشار 2015